John's new Sub Stack link, https://johninengland.substack.....com/publish/post/12

Number of UK people with heart rhythm condition rises by 50% in a decade

https://www.bhf.org.uk/what-we....-do/news-from-the-bh

Atrial fibrillation, 1.5 million sufferers in the UK

1milloin in 2013 – a 50% rise over the decade.

One in 45 people in the UK

Five times more likely to stroke, potentially fatal or life-changing

Believed to contribute to one in five strokes

Estimated, at least another 270,000 people undiagnosed

(= 1,770,000)

Symptoms of atrial fibrillation

Palpitations

Breathlessness

Dizziness

Paroxysmal

Our medical director Professor Sir Nilesh Samani

These figures show a quite astonishing rise in the number of people diagnosed with atrial fibrillation.

Research has helped us understand the links between atrial fibrillation and stroke

We also need to continue to harness the power of science to develop new and innovative tools for identifying people at increased risk

BHF
The figures have been released as we launch a new campaign calling on the public to support our research

The campaign aims to inspire people’s wonder at the complexity and preciousness of their own hearts and how lifesaving research can help if it goes wrong.

Questions

What was the rate of increase or change in prevalence during 2019, 2020, 2021, 2022, 2023?

Has the increase been correlated with any particular factors that have changed between 2019 and 2023?

What is the strength of any possible correlations?

Is there temporality with possible correlations?

Is there a plausible mechanism to explain correlations?

How do UK figures of increased AF relate to other countries?

Are there any common factors that connect potential changes across differing countries?

https://www.thelancet.com/jour....nals/lanepe/article/

June 2022

Data only up to 31 December 2017

https://www.nhs.uk/conditions/atrial-fibrillation/

See a GP or call 111 if:
• you have chest pain that comes and goes
• you have chest pain that goes away quickly but you're still worried
• you notice a sudden change in your heartbeat
• your heart rate is consistently lower than 60 or above 100 (particularly if you're experiencing other symptoms of atrial fibrillation, such as dizziness and shortness of breath)
It's important to get medical advice to make sure it's nothing serious.

John has opened a Substack, https://substack.com/@johninengland

Covid-19 vaccination can induce multiple sclerosis via cross-reactive CD4+ T cells recognizing SARS-CoV-2 spike protein and myelin peptides

https://pesquisa.bvsalud.org/g....lobal-literature-on-

Both natural infection and the mRNA based vaccinations can be accompanied by transient autoimmune phenomena,

or onset of autoimmune diseases.

Objective

Two cases of multiple sclerosis (MS),

with clinical and new radiological signs,

beginning in close temporal relation to spike (S) protein mRNA based vaccinations.

Aim

The onset of MS in these two cases is very likely caused by CD4+ T cell clones,

that cross-recognize SARSCoV- 2 S protein,

from myelin proteins.

Method

Spike specific CD4+ T cells from peripheral blood,

and CD4+ T cells from CSF sample were isolated,

then underwent autoantigen screening test.

(An endogenous antigen that stimulates the production of autoantibodies)

A list of well-known MS related autoantigens,

Result(s)

Self-reactive T cells were detected from Spike specific T cell population,

also showed reactivity to MBP, MOG, (Myelin oligodendrocyte glycoprotein) peptides PLP peptide pools.

Multiple sclerosis and myelin basic protein: insights into protein disorder and disease

https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC88104

Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.

MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS).

MS is characterized by CNS inflammation, demyelination, and axonal loss.

Finally,

we found proinflammatory T cell clones,

that recognize both Spike protein and immunodominant Myelin basic protein peptides,

and Myelin oligodendrocyte glycoprotein (MOG) peptides, which have previously been implicated in MS.

Conclusion(s)

Detailed studies of both peripheral blood, and CSF derived CD4+ T cells show that the onset of MS in these two cases is very likely caused by CD4+ T cell clones that cross-recognize SARS-CoV-2 S protein derived peptides and peptides derived from myelin proteins, which have previously been implicated in MS.

Posts misrepresent research on multiple sclerosis and COVID-19 vaccines found in WHO database

https://apnews.com/article/fac....t-check-WHO-COVID-mu

New diagnosis of multiple sclerosis in the setting of mRNA COVID-19 vaccine exposure (January 2022)

https://pubmed.ncbi.nlm.nih.gov/34922126/

Multiple sclerosis (MS) with onset in the setting of acute SARS-CoV-2 virus infection has been reported,

and reactivation of MS following non-mRNA COVID-19 vaccination has been noted,

There have been three reports of newly diagnosed MS following exposure to mRNA COVID-19 vaccine.

The association cannot be determined to be causal,

We report a series of 5 cases of newly diagnosed MS following recent exposure to mRNA COVID-19 vaccines.

Latency from vaccination to initial presentation varied.
Neurological manifestations and clinical course appeared to be typical for MS,

including response to high dose steroids

Conclusion

Acute neurological deficits in the setting of recent mRNA COVID-19 vaccine administration may represent new onset multiple sclerosis.

Hold a parliamentary vote on whether to reject amendments to the IHR 2005

https://petition.parliament.uk/petitions/635904
https://twitter.com/Johnincarlisle

We are concerned that Parliament has not discussed and will not have a say on the 307 proposed amendments to the International Health Regulations,

AND the amendments to 5 Articles of the IHR that were ADOPTED by the 75th World Health Assembly on 27 May 2022.